Effect of cadmium on the defense response of Pacific oyster Crassostrea gigas to Listonella anguillarum challenge

Heavy metal pollution can affect the immune capability of organisms. We evaluated the effect of cadmium (Cd) on the defense responses of the Pacific oyster Crassostrea gigas to Listonella anguillarum challenge. The activities of several important defensive enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), acid phosphatase (ACP), Na+, K+ -ATPase in gills and hepatopancreas, and phenoloxidase-like (POL) enzyme in hemolymph were assayed. In addition, the expression levels of several genes, including heat shock protein 90 (HSP90), metallothionein (MT), and bactericidal/permeability increasing (BPI) protein were quantified by fluorescent quantitative PCR. The enzyme activities of SOD, ACP, POL, and GPx in hepatopancreas, and the expression of HSP90 were down-regulated, whereas GPx activity in the gill, Na+, K+-ATPase activities in both tissues, and MT expression was increased in Cdexposed oysters post L. anguillarum challenge. However, BPI expression was not significantly altered by co-stress of L. anguillarum infection and cadmium exposure. Our results suggest that cadmium exposure alters the oysters' immune responses and energy metabolism following vibrio infection.Heavy metal pollution can affect the immune capability of organisms. We evaluated the effect of cadmium (Cd) on the defense responses of the Pacific oyster Crassostrea gigas to Listonella anguillarum challenge. The activities of several important defensive enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), acid phosphatase (ACP), Na+, K+ -ATPase in gills and hepatopancreas, and phenoloxidase-like (POL) enzyme in hemolymph were assayed. In addition, the expression levels of several genes, including heat shock protein 90 (HSP90), metallothionein (MT), and bactericidal/permeability increasing (BPI) protein were quantified by fluorescent quantitative PCR. The enzyme activities of SOD, ACP, POL, and GPx in hepatopancreas, and the expression of HSP90 were down-regulated, whereas GPx activity in the gill, Na+, K+-ATPase activities in both tissues, and MT expression was increased in Cdexposed oysters post L. anguillarum challenge. However, BPI expression was not significantly altered by co-stress of L. anguillarum infection and cadmium exposure. Our results suggest that cadmium exposure alters the oysters' immune responses and energy metabolism following vibrio infection

Joint Communication and Computation Design in Transmissive RMS Transceiver Enabled Multi-Tier Computing Networks

In this paper, a novel transmissive reconfigurable meta-surface (RMS) transceiver enabled multi-tier computing network architecture is proposed for improving computing capability, decreasing computing delay and reducing base station (BS) deployment cost, in which transmissive RMS equipped with a feed antenna can be regarded as a new type of multi-antenna system. We formulate a total energy consumption minimization problem by a joint optimization of subcarrier allocation, task input bits, time slot allocation, transmit power allocation and RMS transmissive coefficient while taking into account the constraints of communication resources and computing resources. This formulated problem is a non-convex optimization problem due to the high coupling of optimization variables, which is NP-hard to obtain its optimal solution. To address the above challenging problems, block coordinate descent (BCD) technique is employed to decouple the optimization variables to solve the problem. Specifically, the joint optimization problem of subcarrier allocation, task input bits, time slot allocation, transmit power allocation and RMS transmissive coefficient is divided into three subproblems to solve by applying BCD. Then, the decoupled three subproblems are optimized alternately by using successive convex approximation (SCA) and difference-convex (DC) programming until the convergence is achieved. Numerical results verify that our proposed algorithm is superior in reducing total energy consumption compared to other benchmarks

Information-Theoretic Limits of Integrated Sensing and Communication with Correlated Sensing and Channel States for Vehicular Networks

In connected vehicular networks, it is vital to have vehicular nodes that are capable of sensing about surrounding environments and exchanging messages with each other for automating and coordinating purpose. Towards this end, integrated sensing and communication (ISAC), combining both sensing and communication systems to jointly utilize their resources and to pursue mutual benefits, emerges as a new cost-effective solution. In ISAC, the hardware and spectrum co-sharing leads to a fundamental tradeoff between sensing and communication performance, which is not well understood except for very simple cases with the same sensing and channel states, and perfect channel state information at the receiver (CSIR). In this paper, a general point-to-point ISAC model is proposed to account for the scenarios that the sensing state is different from but correlated with the channel state, and the CSIR is not necessarily perfect. For the model considered, the optimal tradeoff is characterized by a capacity-distortion function that quantifies the best communication rate for a given sensing distortion constraint requirement. An iterative algorithm is proposed to compute such tradeoff, and a few non-trivial examples are constructed to demonstrate the benefits of ISAC as compared to the separation-based approach

The Regenerating Gene Iα Is Overexpressed in Atrophic Gastritis Rats with Hypergastrinemia

The role of gastrin on the development of atrophic gastritis (AG) and its relationship with the expression of RegIα  in vivo remain unclear. We established experimental AG in rats by combination administration with sodium salicylate, alcohol, and deoxycholate sodium. The mean score of inflammation in gastric antrum in AG rats was significantly elevated (P < 0.05), while the number of glands dramatically decreased (P < 0.05). In addition, the cell proliferation in gastric glands was increased in experimental AG rats, as determined by immunohistochemistry staining of PCNA and GS II. The level of serum gastrin in AG rats was significantly elevated relative to that of normal rats (P < 0.01). Moreover, the expression of RegIα protein and its receptor mRNA was increased in gastric tissues in AG rats (P < 0.05). Taken together, we demonstrated that the overexpression of Reglα is related with hypergastrinemia in AG rats

Uplink Transceiver Design and Optimization for Transmissive RMS Multi-Antenna Systems

In this paper, a novel uplink communication for the transmissive reconfigurable metasurface (RMS) multi-antenna system is investigated. Specifically, a transmissive RMS-based receiver equipped with a single receiving antenna is first proposed, and a far-near field channel model is also given. Then, in order to maximize the system sum-rate, we formulate a joint optimization problem over subcarrier allocation, power allocation and RMS transmissive coefficient design. Since the coupling of optimization variables, the problem is non-convex, so it is challenging to solve it directly. In order to tackle this problem, the alternating optimization (AO) algorithm is used to decouple the optimization variables and divide the problem into two subproblems to solve. Numerical results verify that the proposed algorithm has good convergence performance and can improve system sum-rate compared with other benchmark algorithms.Comment: arXiv admin note: text overlap with arXiv:2109.0546

OMAE2006-92140 CHARACTERISTICS OF CURRENT GENERATION SYSTEM IN DEEPWATER OFFSHORE BASIN

ABSTRACT The current generation system in deepwater offshore basin is important for the correct modeling of ocean environment. It is generally considered to be a challenge to obtain uniform and stable current flow in the basin. As technical assurance numerical and experimental studies are performed to investigate the characteristics of the deepwater current generation in the basin. Reynolds-Averaged Navier-Stokes (RANS) equations and the standard k-ε turbulence model are adopted to simulate the current generation system numerically. In addition a 1:10 scaled model test is also performed. In both numerical and experimental studies horizontal and vertical current velocity profiles, turbulence levels and pressure losses during the current recirculation etc. are studied. It is concluded that the perforated walls are key components of the current generation system. In addition various vertical current velocity profiles can be realized in the basin